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DNA Microarrays02:34

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
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Large-Scale Distribution of Physical Data Using DNA-of-Things Technology in Newspaper Printing.

Francesca Granito1, Andreas L Gimpel1, Wendelin J Stark1

  • 1Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

Small (Weinheim an Der Bergstrasse, Germany)
|March 31, 2026
PubMed
Summary
This summary is machine-generated.

This study demonstrates DNA-of-Things technology for data storage by encoding Germany's Basic Law in DNA and embedding it in newspaper ink. The DNA data was successfully retrieved, proving its sensitivity and scalability for printed media.

Keywords:
DNA data storageDNA of thingsnewspapersilica nanoparticles

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Area of Science:

  • Biotechnology
  • Data Storage
  • Materials Science

Background:

  • DNA offers high-density, long-term data storage potential.
  • DNA-of-Things (DoT) technology explores embedding digital data within physical objects.
  • Previous research has focused on DNA data storage but not its integration into mass-produced printed media.

Purpose of the Study:

  • To assess the scalability and robustness of DNA-of-Things technology.
  • To embed digital data encoded in silica-encapsulated DNA into newspaper ink for mass distribution.
  • To demonstrate the feasibility of retrieving and decoding DNA data from printed media.

Main Methods:

  • Digital data representing the German Basic Law was encoded into DNA.
  • DNA was encapsulated in silica nanoparticles.
  • Encapsulated DNA was mixed with paraffin-based offset ink for printing in a newspaper.
  • DNA integrity and recoverability were assessed through retrieval, sequencing, and decoding.

Main Results:

  • The encoded DNA was successfully integrated into newspaper ink and distributed via mass printing.
  • The DNA data remained intact and was reliably retrieved from a single dot of ink.
  • Successful sequencing and decoding confirmed the integrity of the stored data, demonstrating proof of concept.

Conclusions:

  • DNA-of-Things technology is sensitive and scalable for data storage applications.
  • Printed media can serve as a viable medium for robust DNA data storage.
  • This approach enables the secure and long-term archiving of critical information within everyday objects.