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Updated: Mar 17, 2026
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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
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Cellular Senescence in Skeletal Muscle Aging
Yang Li1, Huating Wang2,3
1Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.
Endocrinology and Metabolism (Seoul, Korea)
|March 15, 2026
Summary
Cellular senescence drives muscle aging and sarcopenia by accumulating senescent cells. Senotherapeutics offer a promising approach to restore muscle function and combat age-related decline.
Area of Science:
- Gerontology
- Muscle Biology
- Cellular Biology
Background:
- Cellular senescence is a key driver of skeletal muscle aging and sarcopenia.
- Senescent cells accumulate in aged muscle, affecting various cell types like stem cells, progenitors, immune cells, and myofibers.
Purpose of the Study:
- To review the role of cellular senescence in skeletal muscle aging.
- To explore the impact of senescent cells on muscle regeneration and inflammation.
- To discuss senotherapeutic strategies for combating sarcopenia.
Main Methods:
- Literature review of recent evidence on cellular senescence in skeletal muscle.
- Synthesis of findings on senescent cell accumulation and their effects.
- Analysis of emerging senolytic and senomorphic therapies.
Main Results:
- Senescent cells in aged skeletal muscle impair regenerative signaling and disrupt niche homeostasis.
- Accumulation of senescent cells contributes to chronic inflammation in muscles.
- Senotherapeutics show potential for restoring muscle function.
Conclusions:
- Cellular senescence is a critical factor in skeletal muscle aging and sarcopenia.
- Targeting senescent cells with senolytics or senomorphics is a promising therapeutic avenue.
- Further research is needed to address challenges and explore future directions in skeletal muscle senescence.
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