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Cellular Senescence in Skeletal Muscle Aging.

Yang Li1, Huating Wang2,3

  • 1Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.

Endocrinology and Metabolism (Seoul, Korea)
|March 15, 2026
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Cellular senescence drives muscle aging and sarcopenia by accumulating senescent cells. Senotherapeutics offer a promising approach to restore muscle function and combat age-related decline.

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AgingCellular senescenceSenotherapySkeletal muscle

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Area of Science:

  • Gerontology
  • Muscle Biology
  • Cellular Biology

Background:

  • Cellular senescence is a key driver of skeletal muscle aging and sarcopenia.
  • Senescent cells accumulate in aged muscle, affecting various cell types like stem cells, progenitors, immune cells, and myofibers.

Purpose of the Study:

  • To review the role of cellular senescence in skeletal muscle aging.
  • To explore the impact of senescent cells on muscle regeneration and inflammation.
  • To discuss senotherapeutic strategies for combating sarcopenia.

Main Methods:

  • Literature review of recent evidence on cellular senescence in skeletal muscle.
  • Synthesis of findings on senescent cell accumulation and their effects.
  • Analysis of emerging senolytic and senomorphic therapies.

Main Results:

  • Senescent cells in aged skeletal muscle impair regenerative signaling and disrupt niche homeostasis.
  • Accumulation of senescent cells contributes to chronic inflammation in muscles.
  • Senotherapeutics show potential for restoring muscle function.

Conclusions:

  • Cellular senescence is a critical factor in skeletal muscle aging and sarcopenia.
  • Targeting senescent cells with senolytics or senomorphics is a promising therapeutic avenue.
  • Further research is needed to address challenges and explore future directions in skeletal muscle senescence.