Related Experiment Video
Updated: Mar 17, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Histone lactylation: A sensor of epigenetic reprogramming mediated by cellular metabolism
Lei Wang1, Shuaifei Song1, Shiyi Yao1
1Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
None:
Epigenetic reprogramming plays a critical role in connecting genotype to phenotype, providing the flexibility that allows organisms to adapt to developmental needs, environmental shifts, and disease challenges through the flexible regulation of gene expression. Histone lactylation, a recent modification in the field of epigenetic regulation, directly associates metabolic products-lactate-with chromatin modifications, revealing how cellular metabolism regulates the epigenetic landscape. In this review, we discuss the effects of histone lactylation on transcription and its metabolic regulatory mechanisms, explore the interplay between subnuclear metabolic microdomains and histone acetylation, and highlight the specific 'writing,' 'erasing,' and 'reading' enzymes involved in histone lactylation. Additionally, we discuss the physiological functions and recent advancements in the understanding of histone lactylation in disease progression, emphasizing its scientific significance for future research.
More Related Videos
10:09Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
08:12Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
Published on: May 5, 2022
Related Concept Videos
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Histone Modification
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Epigenetic Regulation
Chromatin Modification in iPS Cells
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...