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Updated: Mar 17, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

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Implementing Health-Related Quality of Life Assessment in Pediatric Oncology: A Feasibility Study

Mikaela Doig1,2,3, Sophie Jessop2, Jordan R Hansford2,3,4

  • 1School of Allied Health and Human Performance, Adelaide University, Adelaide, South Australia, Australia.

Pediatric Blood & Cancer
|March 16, 2026
PubMed

Insights

Implementing an electronic patient-reported outcome measure (ePROM) platform for assessing health-related quality of life (HRQoL) in pediatric cancer patients was feasible and well-received. The study highlights the usability and acceptability of this digital approach in routine clinical care.

Area of Science:

  • Pediatric Oncology
  • Health Informatics
  • Quality of Life Research

Background:

  • Growing interest in integrating health-related quality of life (HRQoL) and patient-reported outcome measures (PROMs) into pediatric cancer care.
  • Need for evaluating digital tools to streamline HRQoL assessment in this population.

Purpose of the Study:

  • To assess the feasibility, acceptability, and usability of an electronic PROM (ePROM) platform for measuring HRQoL in children with cancer.
  • To evaluate the integration of ePROM data into clinical workflows.

Main Methods:

  • A 12-month, multicenter, mixed-methods study involving children (5-12 years) with cancer, parents, and clinicians.
  • Web-based completion of age-appropriate PedsQL™ Generic Core Scales (child and parent-proxy).
  • Evaluation surveys, including the System Usability Scale (SUS), administered to parents and clinicians.

Main Results:

  • High completion rates for PROMs (85% overall; 88% for children, 62% for parents).
  • Excellent usability indicated by a mean SUS score of 88.6.
  • Parents found the platform child-friendly and effective in capturing relevant HRQoL aspects.

Conclusions:

  • Routine HRQoL assessment via an ePROM platform is feasible, acceptable, and usable for pediatric cancer patients (aged 5-12).
  • Preliminary evidence of clinical utility warrants further implementation-effectiveness studies.
Abstract

Keywords:
digital healthhealth‐related quality of lifepatient‐reported outcome measurespediatric oncology

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