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Updated: Mar 17, 2026

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Deployable 3D-Printed Vascular Stent with Surface-Catalysed Endogenous Nitric Oxide Generation.

Kun Zhou1, Zifei Han1,2, Kang Lin1,2

  • 1School of Chemical Engineering, UNSW, Sydney, New South Wales, Australia.

Advanced Materials (Deerfield Beach, Fla.)
|March 16, 2026
PubMed
Summary

A novel 3D-printed vascular stent (DSENO) offers remote deployment via magnetic force and heat, reducing tissue injury. Its surface generates nitric oxide (NO) to prevent restenosis, addressing limitations of traditional angioplasty and stenting.

Keywords:
deployable vascular stentendogenous nitric oxide catalysisshape‐memory materialspatiotemporal control

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Atherosclerosis poses a significant global health challenge, leading to heart attacks and strokes.
  • Current treatments like angioplasty and stenting have limitations including tissue damage, inflammation, and restenosis.
  • Restenosis can cause implant failure and necessitate repeat surgeries, impacting patient quality of life.

Purpose of the Study:

  • To develop a novel, long-term stable vascular stent system.
  • To overcome the limitations of traditional balloon-based angioplasty and stenting.
  • To introduce a stent with reduced invasiveness and enhanced anti-restenosis properties.

Main Methods:

  • Development of a deployable 3D-printed vascular stent (DSENO).
  • Utilized remote deployment via magnetic force and heat, avoiding catheter/balloon use.
  • Modified stent surface to catalyze endogenous nitric oxide (NO) generation from S-nitrosothiols.

Main Results:

  • The DSENO stent enables catheter-free, remote deployment, minimizing tissue injury.
  • Surface-catalyzed NO generation effectively inhibits smooth muscle cell proliferation.
  • The DSENO system presents a promising alternative to conventional stenting methods.

Conclusions:

  • The DSENO stent represents a significant advancement in vascular device technology.
  • Remote deployment and endogenous NO generation offer a safer and more effective approach to treating atherosclerosis.
  • This innovation holds potential for improving patient outcomes and reducing healthcare burdens.