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From pedigrees to practicality: an interactive tool for cat breeding.

Steven R Talbot1, Nora Weegh1, Miriam Heider1

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Summary
This summary is machine-generated.

PawlineR is a new browser-based tool that helps breeders calculate inbreeding coefficients (F) for companion animals. This application automates pedigree analysis and allows virtual breedings to manage genetic diversity and prevent health issues.

Keywords:
feline breedinginbreeding monitoringpedigree managementshiny web applicationvirtual breeding simulation

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Area of Science:

  • Animal Genetics
  • Bioinformatics
  • Companion Animal Science

Background:

  • Accurate inbreeding coefficients are crucial for companion animal breeding programs.
  • Maintaining genetic diversity and minimizing deleterious traits are key goals.
  • Advanced genetic tools are not always accessible to everyday breeders.

Purpose of the Study:

  • To develop a user-friendly, browser-based application (pawlineR) for calculating inbreeding coefficients.
  • To bridge the gap between genetic research and practical breeding applications.
  • To automate pedigree analysis and inbreeding risk assessment for breeders.

Main Methods:

  • Developed pawlineR using R libraries for automated pedigree entry and validation.
  • Calculated inbreeding coefficients (F) in real time.
  • Validated calculations using Wright's formula and a historical cat dataset.
  • Implemented "virtual breeding" simulations for risk assessment.

Main Results:

  • The pawlineR tool accurately calculates inbreeding coefficients.
  • Evaluation on 70 cats identified 24 with moderate to high inbreeding (0.063-0.375).
  • Virtual breeding simulations aid proactive decision-making in mating choices.

Conclusions:

  • PawlineR effectively reduces technical barriers for breeders in managing genetic diversity.
  • The application supports routine breeding management through user-friendly interfaces and data storage.
  • PawlineR's functionality can be extended to other animal species.