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Scalability Metrics and Effort Requirements for a Long-Acting Injectable Antiretroviral Treatment Program.
Joshua P Havens1,2, Jennifer O'Neill1, Maureen Kubat1
1Division of Infectious Diseases, University of Nebraska Medical Center, College of Medicine, Omaha, Nebraska, USA.
Open Forum Infectious Diseases
|March 16, 2026
Summary
Implementing long-acting injectable antiretroviral therapy requires significant effort in coordination and patient support. However, clinical outcomes are favorable, demonstrating the real-world feasibility and scalability of this HIV treatment approach.
Area of Science:
- Infectious Diseases
- Public Health
- Pharmacology
Background:
- Long-acting injectable antiretroviral therapy (ART) offers an alternative to daily oral medications for HIV management.
- Successful implementation necessitates robust operational infrastructure and patient-centered support systems.
Purpose of the Study:
- To evaluate the operational demands and clinical outcomes of a scaled long-acting injectable ART program.
- To assess the feasibility and scalability of this treatment modality in a real-world setting.
Main Methods:
- A multidisciplinary team managed a program serving 113 patients over 2.5 years.
- Operational efforts focused on program coordination, coverage/billing, and patient support/retention.
- Clinical outcomes were monitored to assess treatment effectiveness.
Main Results:
- The program required 2.25 full-time equivalents for operational management.
- Despite operational demands, favorable clinical outcomes were achieved.
- The program demonstrated successful patient retention and adherence.
Conclusions:
- Long-acting injectable ART programs are operationally demanding but clinically effective.
- The findings support the real-world feasibility and scalability of long-acting injectable ART.
- Multidisciplinary collaboration and patient support are crucial for program success.
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