Related Experiment Video
Updated: Mar 17, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[Research Progress on Quorum Sensing-Regulated Oral Microbial Interaction Networks in Periodontitis]
None:
Quorum sensing (QS) is a mechanism by which bacteria communicate and coordinate group behaviors through the secretion of signaling molecules, playing a critical role in oral microbial interactions and the pathogenesis of periodontitis. This review summarizes recent advances in QS-mediated regulation of oral microbial interaction networks in periodontitis, focusing on the molecular mechanisms that modulate biofilm formation, virulence factor expression, and pathogen community dynamics. In addition, novel QS-targeted therapeutic strategies are discussed. Although periodontitis is fundamentally a chronic inflammatory disease driven by oral dysbiosis, the precise mechanisms by which microbes trigger and amplify inflammatory damage through the "community dynamics-host interaction-microenvironment" axis remain unclear. Therefore, exploring novel therapeutic strategies targeting the QS system offers potential targets and innovative approaches for the clinical treatment of periodontitis.
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Bacterial Signaling
Biofilms
Global Regulatory Systems

