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Nonenzymatic Glucose Biosensor Based on Selective Reduction of Silver Ions
Maryam Sarlak1, Shankar B Rananavare1
1Department of Chemistry, Portland State University. Portland, Oregon 97206, United States.
ACS Omega
|March 16, 2026
Summary
This study presents a novel nonenzymatic glucose biosensor for noninvasive measurements in saliva, sweat, and tears. The sensor uses a silver deposition process, achieving an ultralow limit of detection for glucose monitoring.
Area of Science:
- Electrochemistry
- Biosensors
- Nanotechnology
Background:
- Noninvasive glucose monitoring is crucial for diabetes management.
- Existing biosensors often require invasive sampling or lack sensitivity.
Purpose of the Study:
- To develop a nonenzymatic conductivity-based glucose biosensor for noninvasive measurements.
- To achieve an ultralow limit of detection (ULOD) for enhanced glucose sensing.
Main Methods:
- Utilized a Tollens' silvering process for metallic silver deposition on a sensitized surface.
- Employed self-assembled bifunctional thiol/silane surfactant for surface sensitization.
- Fabricated a conductometric sensor with interdigitated silver electrodes and measured impedance changes.
Main Results:
- Achieved a sigmoidal response across a wide glucose concentration range (0.2 mg/dL to 200 mg/dL).
- Demonstrated an ultralow limit of detection (ULOD) of 0.3 × 10-5 mg/dL.
- Observed a percolation transition in silver deposition morphology correlating with conductivity changes.
Conclusions:
- The developed nonenzymatic biosensor offers high sensitivity and stability for glucose detection.
- The sensor's design and mechanism are suitable for noninvasive monitoring in biofluids.
- The findings highlight the potential of conductivity-based sensors for advanced diagnostics.
