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Related Concept Videos

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Standards of Care II

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Gastroesophageal Reflux Disease II: Clinical Features and Management

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Related Experiment Video

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Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
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Clinical Practice Guidelines for Biliary Atresia in Japan, 2nd Edition.

Ryuji Okubo1,2, Tatsuo Kuroda3, Daiki Abukawa4

  • 1Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Journal of Hepato-Biliary-Pancreatic Sciences
|March 16, 2026
PubMed
Summary

Revised clinical practice guidelines for biliary atresia (BA) now align with MINDS standards. These updated guidelines aim to standardize BA management and improve patient treatment outcomes.

Keywords:
Kasai portoenterostomyMINDSbiliary atresiaguidelineliver transplantation

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Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Clinical Practice Guidelines

Background:

  • Biliary atresia (BA) is a rare neonatal liver disease requiring timely intervention.
  • Existing clinical practice guidelines needed updating to reflect current evidence and standards.

Purpose of the Study:

  • To revise the Japanese Biliary Atresia Society's clinical practice guidelines for BA.
  • To ensure adherence to the Medical Information Network Distribution Service (MINDS) Handbook for Clinical Practice Guideline Development 2020 ver.3.0.

Main Methods:

  • Identification of 23 clinical questions (CQs) relevant to BA management.
  • Systematic literature searches and evidence synthesis.
  • Modified Delphi technique for structured consensus and recommendation grading.

Main Results:

  • Recommendations established for 22 out of 23 clinical questions.
  • No recommendation was made for CQ12 concerning laparoscopic surgery due to insufficient evidence.

Conclusions:

  • The second edition of BA clinical practice guidelines has been finalized per MINDS recommendations.
  • These revised guidelines are anticipated to promote standardized BA management and enhance treatment outcomes.