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Mild Behavioral Impairment: A Population-Based Study.

Maria Vassilaki¹, Jeremy A Syrjanen¹, Janina Krell-Roesch^1,2

¹Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.

The Journal of Neuropsychiatry and Clinical Neurosciences

|March 16, 2026

Summary

This summary is machine-generated.

Mild behavioral impairment (MBI) is linked to a higher likelihood of mild cognitive impairment (MCI) in older adults. This study found MBI significantly increases the odds of MCI and lower cognitive scores in aging populations.

Keywords:

Cognitive Disorders Epidemiology of Neuropsychiatric Disorders Mild Behavioral Impairment Neuropsychiatric Symptoms

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Area of Science:

Gerontology
Neuroscience
Psychiatry

Background:

Mild behavioral impairment (MBI) involves new neuropsychiatric symptoms in adults over 50, not caused by psychiatric disorders.
MBI may precede cognitive decline or dementia, making it a critical area of study in aging populations.

Purpose of the Study:

To investigate the prevalence and association of MBI with cognitive status in older adults.
To determine if MBI predicts mild cognitive impairment (MCI) or cognitive decline.

Main Methods:

A population-based study using the Mayo Clinic Study of Aging cohort.
Cross-sectional assessment of 2,713 participants (≥50 years) using the Neuropsychiatric Inventory Questionnaire.
Statistical analysis with linear and logistic regression, adjusted for age, sex, and education.

Main Results:

11% of participants exhibited MBI; 29% of those with MCI had MBI, compared to 10% of cognitively unimpaired individuals.
MBI was significantly associated with higher odds of MCI (OR=3.47) and lower cognitive scores.
Severe MBI showed even stronger associations with MCI (OR=5.15) and cognitive impairment.

Conclusions:

Older adults with MCI are nearly three times more likely to have MBI than cognitively unimpaired individuals.
MBI is a significant indicator associated with increased odds of MCI and diminished cognitive performance.