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Durability of Mitral Valve Transcatheter Edge-to-Edge Repair: An Expert Overview
Andrea Mariani1, Lukas Stolz2, Ralph Stephan von Bardeleben3
1Department of Interventional Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center Rotterdam, the Netherlands; Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
JACC. Cardiovascular Interventions
|March 16, 2026
Summary
Mitral transcatheter edge-to-edge repair (M-TEER) shows increasing failure rates after three years, particularly in primary mitral regurgitation. Further long-term data are needed to fully understand M-TEER durability.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Device Technology
Background:
- Mitral regurgitation (MR) presents a significant global health challenge.
- Mitral transcatheter edge-to-edge repair (M-TEER) offers a minimally invasive treatment option for MR with proven safety and efficacy.
Purpose of the Study:
- To evaluate the long-term durability of M-TEER.
- To identify risk factors and treatment strategies for M-TEER failure.
Main Methods:
- A systematic literature review identified 33 relevant studies.
- Weighted means were calculated for MR recurrence and reintervention rates.
- Analysis included overall, primary, and secondary MR subgroups.
Main Results:
- M-TEER failure rates increased after 3 years, reaching 17% for recurrence and 9% for reintervention at 5 years.
- Primary MR showed higher failure rates (41% at 5 years) compared to secondary MR.
- Redo M-TEER was safer than surgery but had high recurrence rates (20-40% at 1 year).
Conclusions:
- M-TEER failure incidence rises after 3 years, especially in primary MR.
- Longer-term follow-up studies are essential for a comprehensive understanding of M-TEER durability.
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