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Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
Published on: July 6, 2022
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Medial Meniscus Posterior Root Tear Repairs Show Osteoarthritis Progression Over Time With Higher Rates Seen With
Cailan L Feingold1, Eric H Lin1, Joshua M Yazditabar1
1Keck School of Medicine of USC, Los Angeles, California, U.S.A.
Summary
Medial meniscal posterior root repairs show osteoarthritis progression, particularly with higher BMI. Conversion to total knee arthroplasty is infrequent, with most patients avoiding it long-term.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
- Sports medicine
Background:
- Medial meniscal posterior root tears (MMPRT) are increasingly recognized.
- Repair of MMPRT aims to restore knee function and prevent further degeneration.
- Understanding long-term outcomes is crucial for patient management.
Purpose of the Study:
- To evaluate osteoarthritis (OA) development and progression after MMPRT repair.
- To assess the rate of conversion to total knee arthroplasty (TKA) following MMPRT repair.
Main Methods:
- Systematic review adhering to PRISMA guidelines.
- Searched PubMed, Scopus, and Embase for studies on MMPRT repair.
- Included studies reporting OA progression or TKA conversion, excluding case reports and non-English literature.
Main Results:
- Twenty-five moderate-quality studies were included.
- OA progression rates varied with BMI, increasing significantly with higher body mass.
- Conversion to TKA occurred in 48% of studies, with rates from 0-21.6%, and no TKAs within 2 years post-op.
Conclusions:
- MMPRT repair is associated with OA progression, especially in patients with elevated BMI.
- Conversion to TKA is generally low and increases gradually over time.
- Over 75% of patients did not require TKA even after 10 years post-MMPRT repair.
