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Intralesional Methotrexate: A Cost-Effective, High-Efficacy Alternative to Surgery for Cutaneous Squamous Cell
Ashley Lou Rensted1, Alexander Hall1, Joseph Giancola1
1Ashley Lou Rensted is from Creighton University School of Medicine, Omaha, Nebraska. Alexander Hall is from the Department of Research and Compliance, Creighton University School of Medicine, Omaha, Nebraska. Drs. Giancola and Patel are from US Dermatology Partners, Phoenix, Arizona.
None:
Squamous cell carcinoma (SCC) is the second most common type of skin cancer and often is treated surgically. Not all patients are surgical candidates, and sometimes the cost of Mohs micrographic surgery or wide local excision is a barrier for patients. In this study, we explored the use of intralesional methotrexate (IL-MTX) as a treatment for SCC. Our results demonstrate that treatment with IL-MTX could be an excellent option for patients who cannot be treated surgically. However, more research is needed to characterize which lesions are the best candidates for IL-MTX therapy.
