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Published on: August 15, 2019
Role of BARX1 in Development and Disease
Yiwen Ma1, Xiaorui Li1, Liping Xiao1
1Department of Oncology, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Abstract:
Homeobox genes encode diverse proteins, including proteins with highly conserved DNA-binding domains, and are essential for organismal growth, cell differentiation, organ development, and diverse physiological processes associated with diseases. BARX1 encodes a transcription factor containing the BarH1-like homeodomain. This gene plays a significant role in the development of various tissues and is closely associated with the pathogenesis and progression of numerous diseases. In this review, we provide a comprehensive overview of the functional networks and mechanisms of action of the BARX1 gene across different tissue developmental processes and disease contexts.
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