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The influence of lipoprotein(a) on coronary revascularization after percutaneous coronary intervention

Thitiphan Srikulmontri1,2, Suchanart Pantarote3, Narathorn Kulthamrongsri4

  • 1Department of Internal Medicine, Jefferson Einstein Hospital, Philadelphia, PA, USA.

Acta Cardiologica
|March 17, 2026
PubMed

Insights

Elevated Lipoprotein(a) (Lp(a)) levels increase the risk of repeat revascularization and target vessel revascularization after percutaneous coronary intervention (PCI). Further research into Lp(a)-lowering therapies is recommended.

Area of Science:

  • Cardiology
  • Atherosclerosis Research
  • Interventional Cardiology

Background:

  • Lipoprotein(a) (Lp(a)) is a proatherogenic lipoprotein linked to cardiovascular risk.
  • Lp(a) is poorly responsive to statins and lifestyle modifications.
  • The predictive value of Lp(a) for repeat revascularization post-percutaneous coronary intervention (PCI) is not well-established.

Purpose of the Study:

  • To evaluate the association between Lp(a) levels and coronary revascularization outcomes.
  • To determine if elevated Lp(a) predicts repeat revascularization after PCI.

Main Methods:

  • Systematic review and meta-analysis of MEDLINE and EMBASE studies.
  • Included 20 studies (18 in meta-analysis) assessing Lp(a) and revascularization post-PCI.
  • Used random-effects models to pool odds ratios (ORs) and hazard ratios (HRs).

Main Results:

  • Elevated Lp(a) was associated with a higher risk of any repeat revascularization (OR 1.33; HR 1.15).
  • High Lp(a) significantly increased the risk of target vessel revascularization (TVR) (OR 1.42).
  • A non-significant trend towards increased target lesion revascularization (TLR) was observed (OR 1.25).

Conclusions:

  • Elevated Lp(a) levels are linked to increased risk of repeat revascularization and TVR post-PCI.
  • Further research is needed to confirm these findings.
  • Investigating Lp(a)-lowering strategies for cardiovascular risk management is warranted.
Abstract

Keywords:
Lipoprotein(a)percutaneous coronary interventionrevascularization

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