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Related Experiment Video

Updated: Mar 19, 2026

Methods for Intravenous Self Administration in a Mouse Model
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Methods for Intravenous Self Administration in a Mouse Model

Published on: December 8, 2012

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Temporal pattern of oxycodone self-administration in mice.

Cecilia Barajas1, Lukas D Caye2, Parker Jones3

  • 1Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy.

Behavioural Pharmacology
|March 17, 2026
PubMed
Summary

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The time of day significantly impacts opioid-seeking behavior in mice. Overnight access to oxycodone increased seeking in females, highlighting circadian rhythms as a key factor in addiction research.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Opioids like oxycodone are effective analgesics but pose risks of abuse.
  • Rodent self-administration models are crucial for studying substance-seeking behavior and testing interventions.
  • Complex factors influence drug-seeking motivation, with circadian influences often overlooked.

Purpose of the Study:

  • To investigate the impact of time of day on oxycodone-seeking behavior in a preclinical rodent model.
  • To determine if circadian factors influence the motivational drive for opioid consumption.

Main Methods:

  • Utilized a rodent self-administration paradigm to assess oxycodone seeking.
  • Compared oxycodone-seeking behavior in mice with overnight access versus daytime access.
Keywords:
chronopharmacologymouse modelnocturnal behavioropioid self-administrationoxycodoneself-administration

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  • Tested different concentrations of oral oxycodone (30, 200, and 1000 mg/l) and a water control.

    • Main Results:

    • Significant differences in oxycodone-seeking behavior were observed based on access time.
    • Female mice showed increased seeking of 30 and 200 mg/l oxycodone during overnight access compared to daytime access.
    • No significant difference in seeking was observed at 1000 mg/l oxycodone or for water access.

    Conclusions:

    • The time of day is a critical, often overlooked variable in rodent models of drug seeking.
    • Circadian rhythms can substantially modulate the motivational drive for opioids, impacting addiction research.
    • Findings emphasize the need to consider temporal factors in preclinical addiction studies and intervention development.