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Symptom Outcomes After Septal Perforation Surgical Repair Versus 3D-Printed Customized Prosthesis.

Pedro Lança Gomes1,2, Nitish Kumar1, Stephen F Bansberg1

  • 1Department of Otorhinolaryngology, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

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|March 17, 2026
PubMed
Summary

Surgical repair of nasal septal perforations (NSP) led to greater symptom improvement than 3D-printed customized septal prostheses (3D-PCSP). Both treatments offer relief, but individualized decisions are key.

Keywords:
3D‐printed septal prosthesisNOSE‐Perf Scalenasal septal perforationseptal buttonseptal perforation repair

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Area of Science:

  • Otolaryngology
  • Medical Engineering
  • Surgical Innovation

Background:

  • Nasal septal perforations (NSP) present significant challenges for patients.
  • Surgical repair and 3D-printed customized septal prostheses (3D-PCSP) are established treatment options.
  • Objective comparison of clinical outcomes is essential for guiding treatment decisions.

Purpose of the Study:

  • To compare the clinical efficacy of surgical repair versus 3D-PCSP for treating NSP.
  • To evaluate symptom relief using the Nasal Obstruction and Septal Perforation Scale (NOSE-Perf Scale - NPfS).

Main Methods:

  • Retrospective chart review of patients undergoing NSP treatment between January 2018 and July 2024.
  • Primary endpoint: change in NPfS scores post-intervention.
  • Data collected included demographics, ASA score, perforation size, etiology, and follow-up duration.

Main Results:

  • Thirty-five patients were analyzed (23 surgical repair, 12 3D-PCSP).
  • Surgical repair showed a greater reduction in NPfS scores (p=0.018) compared to 3D-PCSP.
  • Both interventions significantly improved NPfS scores (p<0.001 for surgery, p=0.001 for 3D-PCSP).

Conclusions:

  • Both surgical repair and 3D-PCSP provide meaningful symptom relief for NSP patients.
  • Surgical repair demonstrated superior symptom reduction in this cohort.
  • Individualized treatment decisions, considering patient factors and surgeon experience, are recommended.