[Discussion on Management Strategies for Blood Donors with Positive Direct Antiglobulin Tests]

To explore the characteristics of voluntary blood donors with direct antiglobulin test (DAT) positivity and the impact of DAT positivity on blood quality, and to propose a management strategy for these donors.

A retrospective analysis was performed on the relevant data of 80 DAT-positive blood donors from 2020 to 2023, including sex, age, ABO blood group, and blood quality sampling results. Additionally, antibody typing, agglutination strength, and DAT follow-up results from subsequent blood donations were analyzed.

Among DAT-positive blood donors, age was positively correlated with the DAT positivity rate (r =0.8545), while there were no statistically significant differences in DAT positivity rates among donors of different sex and blood groups. IgG antibody was predominant (67.50%), with agglutination strength primarily between 1+ and 2+. There were no statistically significant differences in some blood quality sampling items between DAT-positive and DAT-negative donors (P >0.05). Follow-up results showed that 93.02% of DAT-positive donors had negative DAT results during subsequent donations.

The positivity rate of DAT among blood donors is positively correlated with age. It is recommended to conduct follow-up testing on DAT-positive donors. For rejected DAT-positive blood units, quality sampling tests can be performed to conserve blood resources.