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Association of Preoperative Controlling Nutritional Status (CONUT) Score with the Staging of Cervical Cancer
Mehriban Amatullah1, Shirin Akter Begum2, Tasfia Mahmud3
1Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Background:
Early-stage cervical cancer is commonly managed with radical hysterectomy, followed by "concurrent chemoradiotherapy (CCRT)" in subjects with high-risk pathological features. Nutritional and immune status, as measured by the "Controlling Nutritional Status (CONUT)" score, may predict these adverse outcomes preoperatively.
Objective:
To evaluate the association between preoperative CONUT scores and pathological risk factors for tumor recurrence in early-stage cervical cancer.
Methods:
A cross-sectional analytical research was conducted on 116 subjects with International Federation of Gynecology and Obstetrics stages IA-IIA cervical cancer at a tertiary center in Bangladesh. CONUT scores were calculated based on serum albumin, cholesterol, and lymphocyte count. Associations were examined between CONUT score and recurrence-related factors, including "lymphovascular space invasion (LVSI)," lymph node metastasis, parametrial invasion, and positive resection margin.
Results:
High CONUT scores (≥3) were found in 44.8% of patients. These subjects showed significantly higher rates of LVSI (7.7% vs. 1.6%) and lymph node metastasis (11.5% vs. 3.1%). Overall, high CONUT scores were significantly associated with increased likelihood of at least one recurrence risk factor (P = 0.046).
Conclusion:
High preoperative CONUT scores are predictive of adverse pathological features in early-stage cervical cancer and may aid in risk stratification and personalized treatment planning.
