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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
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Hepatitis B Virus Infection Among Tribal Populations in India: A Systematic Review and Meta-Analysis
Abhinav Sinha1, Gayatree Nanda1, Rounik Talukdar2
1ICMR-Regional Medical Research Center, Bhubaneswar, India.
Public Health Reviews
|March 18, 2026
Summary
Hepatitis B virus (HBV) infection is prevalent in Indian tribal communities, with an overall pooled prevalence of 9.99%. This highlights the need for targeted vaccination strategies to reduce the disease burden in these vulnerable populations.
Area of Science:
- Epidemiology
- Public Health
- Infectious Diseases
Background:
- The Hepatitis B virus (HBV) vaccine has significantly reduced disease burden globally.
- Tribal populations in India represent a substantial demographic (8.6%) requiring specific health assessments.
- Understanding HBV epidemiology in tribal communities is crucial for public health interventions.
Purpose of the Study:
- To synthesize the prevalence of Hepatitis B virus (HBV) infection among tribal populations in India.
- To provide an updated epidemiological overview of HBV in this demographic.
- To inform the development of targeted HBV vaccination strategies.
Main Methods:
- A systematic literature search was conducted across Medline, Embase, CINAHL, and Google Scholar.
- Original observational studies reporting HBV infection markers (primarily HBsAg) in tribal populations were included.
- A meta-analysis was performed to pool prevalence data, with risk of bias assessed using the Appraisal Tool for Cross-Sectional Studies.
Main Results:
- Twenty-four studies were included in the meta-analysis.
- The pooled prevalence of HBV (HBsAg positivity) among Indian tribes was estimated at 9.99% (95% CI 6.07-14.75).
- Prevalence varied by region, with the northern zone showing the highest rate (19.60%), followed by the northeastern (13.43%) and southern zones (10.44%).
Conclusions:
- A considerable prevalence of HBV infection exists within tribal communities in India.
- The findings underscore the importance of addressing HBV in these populations.
- This data is vital for planning and implementing effective HBV vaccination programs for Indian tribes.
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