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Updated: Mar 19, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
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Structural Optimization of Benzyl-5-methyl‑1H‑Imidazole Derivatives as Human Glutaminyl Cyclase Inhibitors

Yu-Ting Chen1, Fan-Bo Meng1, Yu-Qing Zhuang1

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

ACS Medicinal Chemistry Letters
|March 18, 2026
PubMed

Keywords:
CD47Cancer immunologyGlutaminyl cyclasePyroglutamateStructural optimization

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