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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Cervical lymph node TB: diagnostic yield and patient profile.

F R Luba1, P Ghosh1,2,3, S Anwar4

  • 1Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

IJTLD Open
|March 18, 2026
PubMed
Summary

Cervical lymph node tuberculosis (CL-TB) is often underdiagnosed. Combining cytopathology with GeneXpert or PCR offers near-perfect detection, improving diagnosis in high-burden areas.

Keywords:
Bangladeshcytopathologydiagnosisextra-pulmonary TBtuberculosis

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Cervical lymph node tuberculosis (CL-TB) is the most common form of extrapulmonary TB.
  • CL-TB is underdiagnosed in endemic regions due to vague symptoms and inconsistent diagnostic methods.
  • Tertiary hospitals in Bangladesh face challenges in diagnosing CL-TB.

Purpose of the Study:

  • To identify socio-demographic and clinical predictors of CL-TB in Bangladeshi patients.
  • To evaluate the diagnostic yield of various tests for CL-TB.
  • To establish a feasible diagnostic pathway for CL-TB in high-burden settings.

Main Methods:

  • A cross-sectional study was conducted at Bangladesh Medical University.
  • 104 patients with presumptive CL-TB were enrolled from 3,619 cervical lymphadenitis cases.
  • Lymph node aspirates were analyzed using microscopy, cytopathology, GeneXpert, PCR, and culture.

Main Results:

  • 52 out of 104 participants were confirmed to have CL-TB.
  • Younger age (18-30 years) and purulent aspirate were linked to CL-TB.
  • Cytopathology (82.7%) and GeneXpert (71.2%) showed the highest diagnostic yields; microscopy and culture were <7%.

Conclusions:

  • Combining cytopathology with GeneXpert or PCR achieves near-perfect CL-TB detection.
  • This study pioneered direct lymph node aspirate PCR in Bangladesh alongside other methods.
  • The findings suggest an improved, feasible diagnostic approach for CL-TB in high-prevalence areas.