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Related Experiment Video

Updated: Mar 19, 2026

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Responsiveness of the NAIL-Q Patient-Reported Outcome Measure.

Carrie A Forman1, Charlene Rae2, Kaya L Curtis1

  • 1Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

Journal of Cutaneous Medicine and Surgery
|March 18, 2026
PubMed
Summary

The NAIL-Q effectively measures patient-reported outcomes for nail conditions like psoriasis and onychomycosis. This study confirms its responsiveness in assessing treatment effectiveness for various nail disorders.

Keywords:
nail disordersnail psoriasisonychomycosispatient-reported outcomesquality of lifevalidation

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Area of Science:

  • Dermatology and Patient-Reported Outcome Measures (PROMs).

Background:

  • Nail conditions represent approximately 10% of dermatological issues, significantly impacting patient quality of life.
  • The NAIL-Q is a PROM designed for patients with fingernail or toenail conditions, but its responsiveness was unestablished.

Purpose of the Study:

  • To evaluate the responsiveness of the NAIL-Q in patients undergoing treatment for nail psoriasis, onychomycosis, brittle nails, and retronychia.

Main Methods:

  • A prospective validation study involving 142 patients newly diagnosed with nail conditions at a US dermatology clinic.
  • Participants completed the NAIL-Q at baseline, 3, and 6 months, with responsiveness assessed via hypothesis testing and calculation of minimally important differences (MIDs).

Main Results:

  • Hypothesis testing confirmed the validity of the NAIL-Q's change score for Appearance (88%), Nail Symptoms (80%), and Outcome (91%) scales.
  • Moderate effect sizes were observed for Appearance, Nail Distress, and Outcome scales (0.6-0.7), with MIDs ranging from 9 to 14.

Conclusions:

  • The NAIL-Q demonstrated sufficient evidence of responsiveness in patients treated for nail psoriasis, onychomycosis, brittle nails, and retronychia.
  • The study validates the NAIL-Q as a responsive measure for assessing treatment outcomes in diverse nail conditions.