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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Janus-faced coordination chemistry of pyridyl-functionalized phosphinines with Cu(I) and Au(I)
Richard O Kopp1, Nathan T Coles1,2, Moritz J Ernst1
1Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195 Berlin, Germany. c.mueller@fu-berlin.de.
Abstract:
The novel 2,6-trimethylsilyl-3,5-(2'-pyridyl)phosphinine has been synthesized and its coordination chemistry with Cu(I) and Au(I) was investigated. Selective binding through either the phosphorus atom or the pendant pyridyl groups was achieved, yielding monomeric, dimeric, and polymeric complexes. The use of copper halides produced rather structurally diverse coordination compounds, with architectures dependent on the type of halide, copper loading, and solvent, whereas Au(I) exclusively formed monomeric species. Quaternization of the ligand with alkylating agents suppressed N-coordination, enabling further study of the resulting cationic derivative with the same metals. These results highlight strongly tuneable coordination behaviour of this new phosphinine scaffold.
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