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Social Mixing Patterns and Chikungunya Reemergence Risk in French Polynesia.

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High chikungunya virus seroprevalence was found in French Polynesia. Modeling suggests potential for sustained transmission if reintroduced, highlighting the need for accurate outbreak risk assessments.

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Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Chikungunya virus (CHIKV) reemergence in French territories necessitates understanding population immunity and future outbreak risks.
  • French Polynesia, a Southeast Pacific archipelago, faces potential CHIKV reintroduction.

Purpose of the Study:

  • To assess CHIKV population immunity in French Polynesia.
  • To estimate the risk of future CHIKV outbreaks in the region.

Main Methods:

  • Cross-sectional study utilizing two serosurveys (2018, 2019-2021) of schoolchildren and adults.
  • Integrated seroprevalence data with contact matrices and demographic characteristics for modeling.
  • Estimated age-stratified infection proportions, basic reproduction number (R0), and effective reproduction number (Reff).

Main Results:

  • High seroprevalence observed: 62.8% in schoolchildren and 67.6% in adults.
  • Factors associated with lower adult seropositivity included male sex, older age groups, Austral subdivision residence, and higher education.
  • Estimated Reff near 1 (0.95) for 2025, with projections indicating potential exceedance of 1 by 2028 (assortative mixing) or 2051 (random mixing).

Conclusions:

  • French Polynesia exhibits high CHIKV seroprevalence with significant sociodemographic heterogeneity.
  • The estimated Reff near 1 suggests sustained transmission is possible upon CHIKV reintroduction.
  • Contact matrix modeling improves outbreak risk assessment, while random mixing models may underestimate reemergence timing.