Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent Papular Eruption on the Bilateral Elbows: Answer.

The American Journal of dermatopathology·2026
Same author

Widespread Symmetrical and Papular Lichenoid Eruption: Answer.

The American Journal of dermatopathology·2026
Same author

Recurrent Papular Eruption on the Bilateral Elbows: Challenge.

The American Journal of dermatopathology·2026
Same author

Widespread Symmetrical and Papular Lichenoid Eruption: Challenge.

The American Journal of dermatopathology·2026
Same author

Hippocampal CA1 and CA2 dendritic compartment-specific differences in mitochondrial form and function.

Progress in neurobiology·2026
Same author

Pancreatic Panniculitis: Silent Conundrum?

The American Journal of dermatopathology·2026
Same journal

Herpetic Whitlow in Association With a Cutaneous Infiltrate of Chronic Lymphocytic Leukemia.

The American Journal of dermatopathology·2026
Same journal

Basal Cell Carcinosarcoma with an Osteosarcomatous Component: A Case Report Supporting the Diagnostic Utility of SATB2 and TRAP Immunostaining with a Literature Review of 22 Cases.

The American Journal of dermatopathology·2026
Same journal

Demonstration of 23-Gene Expression Profile Test Utility Within PRAME Immunohistochemistry Results: A Case Series.

The American Journal of dermatopathology·2026
Same journal

On the Progression From Early-to Late-Stage Melanoma: A Potential Sequence of Molecular Events Using Data From Droplet Digital PCR and Array Comparative Genomic Hybridization, A Pilot Study.

The American Journal of dermatopathology·2026
Same journal

Montgomery Tubercles in the Male Areola: Histological Observations and a Brief About Past Investigators.

The American Journal of dermatopathology·2026
Same journal

Metastatic Syringocystadenocarcinoma Papilliferum Mimicking Cutaneous Squamous Cell Carcinoma of Unknown Primary in a Young Patient.

The American Journal of dermatopathology·2026
See all related articles

Related Experiment Video

Updated: Mar 20, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K

Nonconventional MYC-Positive Primary Cutaneous Angiosarcoma: Novel or Untested.

Renesa Tarannum1, Morgan Parker2, Douglas J Grider2,3,4,5

  • 1Virginia Polytechnic Institute and State University, Fralin Biomedical Research Institute at VTC, Roanoke, VA.

The American Journal of Dermatopathology
|March 18, 2026
PubMed
Summary
This summary is machine-generated.

A rare angiosarcoma case shows MYC gene gain without typical risk factors like lymphedema or radiation. This finding suggests MYC dysregulation may drive angiosarcoma pathogenesis in unexpected ways.

Keywords:
MYC amplificationMYC overexpressionnonradiation angiosarcomaprimary angiosarcoma

More Related Videos

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.5K

Related Experiment Videos

Last Updated: Mar 20, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

15.3K
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

10.4K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

7.5K

Area of Science:

  • Oncology
  • Genetics
  • Dermatopathology

Background:

  • Angiosarcoma is an aggressive endothelial cancer often linked to radiation or lymphedema.
  • MYC gene amplification is frequently observed in secondary angiosarcomas.
  • Primary cutaneous angiosarcoma (pc-AS) typically lacks these predisposing factors.

Purpose of the Study:

  • To report a rare case of primary cutaneous angiosarcoma with MYC gain.
  • To investigate the potential role of MYC in angiosarcoma pathogenesis outside of typical risk factors.
  • To explore MYC gain as a potential diagnostic marker in pc-AS.

Main Methods:

  • Histopathological examination of pc-AS.
  • Immunohistochemistry for CD31 and MYC expression.
  • Fluorescence in situ hybridization (FISH) for MYC copy number analysis.

Main Results:

  • A 65-year-old woman presented with pc-AS without prior radiation or lymphedema.
  • Histopathology showed a poorly differentiated angiosarcoma with high mitotic activity.
  • FISH revealed MYC copy number gain, suggesting whole or partial gain of chromosome 8.
  • Strong CD31 and nuclear MYC expression were confirmed.

Conclusions:

  • This case highlights MYC gain in a primary angiosarcoma unrelated to radiation or lymphedema.
  • MYC dysregulation may contribute to angiosarcoma development in diverse clinical settings.
  • MYC gain could be a valuable addition to the diagnostic work-up for pc-AS.