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Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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Related Experiment Video

Updated: Apr 14, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Pancreatic Panniculitis: Silent Conundrum?

Cheuk Ying Chu¹, Samuel M Wilson², Mariana A Phillips^1,3

¹Virginia Tech Carilion School of Medicine, Roanoke, VA.

The American Journal of Dermatopathology

|April 13, 2026

Summary

This summary is machine-generated.

Pancreatic panniculitis, a rare skin condition linked to pancreatic issues, can manifest without typical abdominal pain. This highlights the need for broader diagnostic considerations in patients presenting with subcutaneous nodules.

Keywords:

pancreatitis panniculitis saponification

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Published on: January 9, 2026

Area of Science:

Dermatology
Gastroenterology
Pathology

Background:

Pancreatic panniculitis is a rare skin condition associated with pancreatic diseases like pancreatitis or neoplasms.
Typically, pancreatic pathology is diagnosed before or concurrently with skin lesions.
However, panniculitis can sometimes precede the pancreatic diagnosis.

Purpose of the Study:

To describe two cases of pancreatic panniculitis in patients who did not experience abdominal pain.
To emphasize the importance of considering pancreatic panniculitis even in the absence of classic abdominal symptoms.

Main Methods:

Case report of two patients with pancreatic panniculitis.
Clinical presentation, histological findings, and pancreatic evaluation were documented.
Focus on patients lacking typical abdominal pain associated with pancreatic disease.

Main Results:

Histological examination revealed lobular panniculitis with fat necrosis and anucleate "ghost" adipocytes, which are pathognomonic findings.
Patients presented with tender subcutaneous nodules, primarily on the lower extremities.
Neither patient reported abdominal pain, a common symptom in pancreatic disease.

Conclusions:

Pancreatic panniculitis can occur in patients without abdominal pain, challenging typical diagnostic pathways.
The characteristic histological findings remain crucial for diagnosis.
Clinicians should maintain a high index of suspicion for pancreatic panniculitis in patients with unexplained subcutaneous nodules, regardless of abdominal symptoms.