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PDAFormer 3+: A full-scale connected modified transformer with parallel dual attention for 3D medical image
Jinhui Zhang1, Yueyang Gao1, Jian Liu1
1School of Automation, Beijing Institute of Technology, Beijing 100081, China.
Artificial Intelligence in Medicine
|March 18, 2026
Summary
This study introduces PDAFormer 3+, a novel framework for 3D medical image segmentation. It enhances accuracy and efficiency by combining convolutional neural networks (CNNs) and transformers for improved diagnostic and therapeutic outcomes.
Area of Science:
- Medical Imaging
- Artificial Intelligence
- Computer Vision
Background:
- Medical image segmentation is crucial for diagnostics, therapy, and research.
- Transformers offer advantages in capturing long-range dependencies, overcoming limitations of Convolutional Neural Networks (CNNs) in global context modeling.
Purpose of the Study:
- To propose PDAFormer 3+, a 3D medical image segmentation framework using a modified transformer with parallel dual attention.
- To enhance segmentation accuracy and computational efficiency for large-scale 3D medical images.
Main Methods:
- Introduced a parallel dual attention (PDA) mechanism for spatial and channel dependency modeling.
- Replaced transformer's MLP with a residual convolution block (RCB) for reduced complexity and enhanced local representations.
- Incorporated full-scale features and a convolution excitation module (CEM), inspired by U-Net 3+, with deep supervision.
Main Results:
- PDAFormer 3+ achieved high mean Dice Similarity Coefficients (DSC): 86.90% on Synapse, 92.54% on ACDC, and 91.93% on type-B AD.
- Demonstrated significant reduction in computational burden for large-scale 3D medical images.
- Maintained strong efficiency alongside high accuracy.
Conclusions:
- PDAFormer 3+ effectively integrates CNNs and transformers, leveraging local details and global context for accurate and efficient 3D medical image segmentation.
- The framework shows promise for improving diagnostic accuracy and healthcare efficiency.

