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Response to comment on "Impact of actigraphy-based circadian rest-activity rhythms on functional outcomes in

Yu-Hsuan Lin1, Kuan-Lin Sung2, Huey-Wen Liang3

  • 1Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan; Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|March 18, 2026
PubMed
Abstract

No abstract available in PubMed .

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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