Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Role of Ion Channels in Neuronal Computation

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....

Mechanically-gated Ion Channels

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...

Mechanically-gated Ion Channels

Mechanically-gated Ion Channels

Non-gated Ion Channels

Non-gated Ion Channels

Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....

Non-gated Ion Channels

Non-gated Ion Channels

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Large language models for systematic reviews were reported to perform well but rarely with verifiable safeguards: a cross-sectional study.

Journal of clinical epidemiology·2026

Same author

Direct Thermal Resistance Measurement of a Single Defect in Graphite.

ACS nano·2026

Same author

SmartEBM AI Agent: A Web-based Platform for Streamlining Network Meta-Analysis via Human-AI Collaboration.

Complementary medicine research·2026

Same author

Large-Scale Integration of Experimental and Computational Data for 2D Materials.

ACS nano·2026

Same author

Point defects in monolayer WSi<sub>2</sub>N<sub>4</sub> and MoSi<sub>2</sub>N<sub>4</sub>.

Nature communications·2026

Same author

High-temperature probe of electron compressibility via asymmetric Coulomb drag.

Nature communications·2026

Same journal

Interplay between oxygen redox and interfacial stability of Li-rich positive electrodes in sulfide-based all-solid-state batteries.

Nature communications·2026

Same journal

Breaking dependence on melanisation imparts diversity to a dogmatic invasion strategy of phytopathogenic fungi.

Nature communications·2026

Same journal

Hydroxyl-rich nanocavities on perovskite enable nearly barrierless intramolecular hydrogen transfer for nitrate electroreduction to ammonia.

Nature communications·2026

Same journal

Household mobility responses to weather extremes in Kyrgyzstan.

Nature communications·2026

Same journal

Autonomous Motion Vision with Tri-bulk-heterojunctioned Organic Adaptation Transistor.

Nature communications·2026

Same journal

Tissue-adhesive hydrogel optical fiber for peripheral optogenetic neuromodulation.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 20, 2026

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

Multimodal ion-gated transistor based on 2D superionic conductor for in-memory computing in deep learning.

Bo Tong^1,2, Tianming Du³, Jinhong Du^1,2

¹Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

Nature Communications

|March 19, 2026

Summary

This summary is machine-generated.

Researchers developed a novel transistor for neuromorphic computing that integrates multiply-accumulate and nonlinear activation functions. This device achieves high accuracy in tasks like handwritten digit classification, paving the way for efficient AI hardware.

More Related Videos

Scalable Quantum Integrated Circuits on Superconducting Two-Dimensional Electron Gas Platform

Scalable Quantum Integrated Circuits on Superconducting Two-Dimensional Electron Gas Platform

Published on: August 2, 2019

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Mar 20, 2026

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes

Published on: March 9, 2019

Scalable Quantum Integrated Circuits on Superconducting Two-Dimensional Electron Gas Platform

Scalable Quantum Integrated Circuits on Superconducting Two-Dimensional Electron Gas Platform

Published on: August 2, 2019

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Area of Science:

Materials Science
Device Physics
Artificial Intelligence Hardware

Background:

Neuromorphic computing aims to mimic the brain's efficiency by integrating computational functions.
Simultaneously achieving linear multiply-accumulate and nonlinear activation in a single device presents significant material and engineering challenges.
Existing approaches often require separate components, increasing latency and power consumption.

Purpose of the Study:

To design and fabricate a single device capable of performing both multiply-accumulate and nonlinear activation operations for neuromorphic computing.
To overcome the conflicting material requirements for these two distinct functions.
To demonstrate the device's potential for efficient AI hardware applications.

Main Methods:

Fabrication of a multimodal ion-gate transistor utilizing a 2D CdPS₃-Li dielectric layer and MoS₂ channel.
Exploitation of the layered CdPS₃-Li structure for anisotropic ion transport and Li⁺ storage.
Leveraging Cd vacancies in CdPS₃-Li to trap photo-generated holes from MoS₂ for nonlinear activation.

Main Results:

The fabricated transistor exhibited high-linearity and non-volatile resistance states under electrical pulses due to strong ion-electron coupling.
The device demonstrated rich nonlinear behavior under light pulses, attributed to Cd vacancies interacting with photo-generated holes.
The CdPS₃-Li transistor arrays achieved high accuracy in handwritten digit classification tasks.

Conclusions:

A single transistor device capable of simultaneously performing multiply-accumulate and nonlinear activation operations has been successfully demonstrated.
The unique properties of the 2D CdPS₃-Li/MoS₂ heterostructure enable the integration of conflicting functionalities.
This multimodal transistor offers a promising hardware solution for low-latency, high-efficiency neuromorphic computing systems.