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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

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Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
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Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

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Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Related Experiment Video

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Inhalable Therapeutics in Lung Cancer: Overcoming Barriers for Effective Treatment.

Himanshu Paliwal1, Tejas Rangbhal2, Pratiksha Khedkar2

  • 1Marwadi University Research Center, Faculty of Pharmacy, Marwadi University, Rajkot, 360003, Gujarat, India. himanshupaliwal.2016@gmail.com.

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|March 19, 2026
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Summary

Inhalation drug delivery offers a promising approach for targeted lung cancer (LC) therapy, improving treatment efficacy and reducing side effects. Overcoming challenges in formulation and delivery is key to advancing this innovative lung cancer treatment strategy.

Keywords:
inhalational drug deliverylung cancernanoparticlespulmonary deliverytargeted therapy

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Area of Science:

  • Pulmonary Medicine
  • Oncology
  • Drug Delivery Systems

Background:

  • Lung cancer (LC) remains a leading cause of cancer mortality globally, often due to late detection and limited conventional therapy effectiveness.
  • Inhalation drug delivery presents a targeted strategy for lung cancer treatment, enhancing drug bioavailability and minimizing systemic toxicity.

Purpose of the Study:

  • To provide a comprehensive review of inhalation formulations for lung cancer therapy.
  • To explore molecular pathways in lung cancer progression and identify therapeutic targets.
  • To discuss challenges and strategies for clinical translation of inhalation systems.

Main Methods:

  • Review of current literature on inhalation formulations for lung cancer.
  • Analysis of molecular pathways and treatment targets in lung cancer.
  • Exploration of strategies to overcome clinical translation barriers.

Main Results:

  • Inhalation systems demonstrate potential for improved drug delivery, bioavailability, and patient outcomes in lung cancer.
  • Key molecular pathways and treatment targets for lung cancer have been identified.
  • Challenges include formulation instability, physiological barriers, patient variability, and immune responses.

Conclusions:

  • Inhalation systems hold significant promise for transforming lung cancer management.
  • Strategies like nanocarrier modification, stimuli-sensitive systems, and immunomodulation are crucial.
  • Personalized medicine and combination therapies are vital for future lung cancer treatment advancements.