Biomimetic nanoplatform with multienzyme cascade activity boosting ROS generation and immune activation feedback for...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Cancer Therapy

Background:

• Nanocatalytic medicine uses nanozymes to produce reactive oxygen species (ROS) for tumor treatment.
• Current limitations include low catalytic efficiency and poor tumor targeting.

Purpose of the Study:

• To develop a tumor cell membrane-coated biomimetic nanozyme platform (CMNP) for enhanced tumor therapy.
• To improve catalytic efficiency and tumor targeting using a multi-component nanoplatform.

Main Methods:

• Constructed a CMNP with manganese dioxide nanoparticles (MnO2@BSA), nano-realgar (NR), and doxorubicin (DOX).
• Investigated MnO2's role in alleviating tumor hypoxia and enhancing NR activity.
• Assessed NR's glutathione oxidase (GSHOx) and L-cysteine oxidase (LCO) activities for ROS generation.

Main Results:

• The CMNP demonstrated enhanced ROS generation through cascade catalysis.
• The platform induced tumor cell apoptosis and activated anti-tumor immune responses.
• Doxorubicin and Mn2+ ions promoted immunogenic cell death (ICD) and activated the cGAS-STING pathway.

Conclusions:

• The developed nanoplatform offers a dual-action strategy for tumor suppression via ROS generation and immune activation.
• Biomimetic coating enhances tumor targeting and therapeutic efficacy.
• This versatile platform shows promise for advanced cancer treatment approaches.