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Updated: Mar 20, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Comparative Clinical Evaluation of Platelet-Rich Fibrin with and Without Bioactive Glass Graft (PerioGlas) In
Manimekalai1, Abhijit Datta2, Shanvi Ray3
1Department of Periodontics, Chettinad Institute of Higher Education and Research, Kelambakkam, Chennai, Tamil Nadu, India.
Introduction:
Furcation involvement, being one of the most common complications of periodontal disease, is managed by a variety of materials, including autografts, allografts, xenografts, and barrier membranes. The bioactive glass ceramic bone graft PerioGlas exhibits both osteoconductive and biointeractive qualities, and platelet-rich fibrin (PRF) may facilitate the healing of both soft and hard tissues. Objective: The purpose of this clinical study was to compare the results of PRF alone and PRF with PerioGlas in mandibular Grade II furcation defects.
Methods:
Ten patients with bilateral mandibular molar furcations participated in a split-mouth study, which evaluated radiographic and clinical parameters at baseline, three months, and six months.
Results:
At six months, both groups had significantly improved, with PRF + PerioGlas producing more bone fill and a smaller defect.
Conclusion:
PRF works well on a standalone basis, but when combined with PerioGlas, it offers better regenerative results in Grade II furcation defects.
