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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

310
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

796
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

324
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
324
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

305
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Related Experiment Video

Updated: Mar 20, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Clinical differences between elderly and non-elderly chronic subdural hematoma patients.

Yongxiang Yang1, Dongbo Zou1, Yuan Ma1

  • 1Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, China.

Frontiers in Neurology
|March 19, 2026
PubMed
Summary

Elderly patients with chronic subdural hematoma (CSDH) are more likely female, less likely to have trauma, and more likely to use anticoagulants/antiplatelet drugs. They also show higher recurrence rates and longer hospital stays compared to younger individuals.

Keywords:
chronic subdural hematomaclinical characteristicsclinical outcomeelderlynon-elderly

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Area of Science:

  • Neurosurgery
  • Geriatric Medicine
  • Neurology

Background:

  • Chronic subdural hematoma (CSDH) is prevalent in the elderly.
  • Understanding clinical differences between elderly and non-elderly CSDH patients is crucial for tailored treatment.

Purpose of the Study:

  • To investigate and clarify the clinical distinctions between elderly and non-elderly patients diagnosed with chronic subdural hematoma (CSDH).

Main Methods:

  • A retrospective study analyzed 268 elderly and 87 non-elderly CSDH patients from January 2015 to December 2024.
  • Data collected included baseline clinical features, radiological outcomes, treatment methods, and clinical outcomes.

Main Results:

  • Elderly CSDH patients were more frequently female, less commonly associated with trauma, and more often had a history of anticoagulant/antiplatelet use (P < 0.05).
  • Elderly patients exhibited thicker, larger hematomas, more frequent atorvastatin use, higher recurrence rates, and longer hospital stays (P < 0.05).

Conclusions:

  • Elderly CSDH patients present with distinct clinical profiles, including less trauma history and increased anticoagulant/antiplatelet use.
  • Higher rates of atorvastatin use and hematoma recurrence are observed in elderly CSDH patients compared to their non-elderly counterparts.