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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Elevated Peripheral White Blood Cell Count and Lower Urinary Tract Symptom Risk: A Population-Based Cross-Sectional
Zheng Lu1, Jiange Zhang2, Zhenyuan Yu1
1Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
Research and Reports in Urology
|March 19, 2026
Summary
Elevated peripheral white blood cell (WBC) counts are linked to increased risks of lower urinary tract symptoms (LUTS) in men. This suggests systemic inflammation may play a role in LUTS development.
Area of Science:
- Urology
- Inflammation Research
- Public Health
Background:
- Lower urinary tract symptoms (LUTS) significantly impact men's quality of life.
- The underlying mechanisms of LUTS are not fully understood, with potential roles for inflammation.
Purpose of the Study:
- To examine the association between peripheral white blood cell (WBC) count and LUTS in a male population.
- To explore the potential role of systemic inflammation in LUTS pathogenesis.
Main Methods:
- A population-based cross-sectional survey was conducted with 4,694 males aged 18-88 years.
- Multistage cluster sampling was employed for participant enrollment.
- Multivariable logistic regression models analyzed the WBC-LUTS association.
Main Results:
- Moderate/severe LUTS prevalence was 6.67%.
- Men with moderate/severe LUTS had significantly higher mean WBC counts (P<0.01).
- Elevated WBC levels were independently associated with increased risks of overall LUTS (OR=1.93) and voiding symptoms (OR=1.68). Higher WBC quartiles showed greater prevalence of intermittency and urgency.
Conclusions:
- LUTS severity positively correlates with peripheral WBC counts.
- Systemic inflammation, indicated by elevated WBC, may contribute to LUTS pathogenesis.
- Age, hypertension, lower education, diabetes, and alcohol consumption were additional LUTS risk factors.
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