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Platinum Contamination from Filament-Based Puller and Its Influence on Micro/Nanopipette Properties.

Qingqing Yu1, Xinqian Xu2,3, Xinyue Zhang3

  • 1Department of Histology and Embryology, School of Basic Medical Sciences, Xuzhou Medical University, Xuzhou 221004, China.

Analytical Chemistry
|March 19, 2026
PubMed
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Platinum filament pullers contaminate micro/nanopipettes with platinum deposits. These residues create catalytic activity and gold film formation, impacting instrument performance and offering functionalization opportunities.

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Micro/nanopipettes are crucial tools in various scientific applications.
  • Fabrication methods can inadvertently introduce contaminants.
  • Surface properties of micro/nanopipettes significantly influence their performance.

Purpose of the Study:

  • To investigate surface contamination on micro/nanopipettes fabricated using a platinum filament puller.
  • To characterize the nature and location of platinum deposits.
  • To evaluate the catalytic and chemical effects of these contaminants.

Main Methods:

  • Fabrication of micro/nanopipettes using a P-97/P-1000 puller with a platinum filament.
  • Characterization of surface deposits using analytical techniques (implied).

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  • Quantification of platinum content based on heating parameters (HEAT) and duration.

    • Main Results:

    • Platinum (Pt0 and Pt2+) deposits were observed on the outer walls of fabricated micro/nanopipettes.
    • These platinum residues exhibited catalytic activity towards hydrogen peroxide.
    • Ethanol-mediated reduction of chloroauric acid was promoted, forming a gold film.
    • Platinum content increased significantly with higher heating parameters and longer heating durations.
    • Contaminants were localized in the thermally affected region near the pipet tip.

    Conclusions:

    • The fabrication process using platinum filament pullers introduces inherent surface contamination.
    • These platinum contaminants can alter the chemical and catalytic properties of micro/nanopipettes.
    • Understanding and controlling these deposits are essential for reliable instrument performance.
    • Tailored deposition offers a potential strategy for controlled functionalization of pipet tips.