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Patient-Specific 3D Coronary Reconstruction and Computational Simulations to Guide Drug-Coated Balloon Intervention:
Wei Wu1, Rakshita Ramesh Bhat1, Shijia Zhao1
1Center for Digital Cardiovascular Innovations, Cardiovascular Division, Miller School of Medicine, Miami, Florida, USA.
JACC. Case Reports
|March 19, 2026
Summary
Patient-specific computational simulations guided the first use of a paclitaxel-coated balloon for in-stent restenosis (ISR) in the US. This approach optimized lesion preparation and device selection, leading to successful outcomes in ISR treatment.
Area of Science:
- Cardiovascular Interventions
- Medical Imaging and Simulation
- Biomedical Engineering
Background:
- In-stent restenosis (ISR) remains a significant challenge in percutaneous coronary intervention.
- Effective patient selection and lesion preparation are crucial for successful drug-coated balloon (DCB) therapy.

