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Updated: Mar 21, 2026
Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
Published on: February 18, 2020
Patient-Specific 3D Coronary Reconstruction and Computational Simulations to Guide Drug-Coated Balloon Intervention:
Wei Wu1, Rakshita Ramesh Bhat1, Shijia Zhao1
1Center for Digital Cardiovascular Innovations, Cardiovascular Division, Miller School of Medicine, Miami, Florida, USA.
Background:
In-stent restenosis (ISR) continues to be a significant challenge in percutaneous coronary intervention, making patient selection and lesion preparation critical for successful drug-coated balloon therapy.
Report Summary:
We report the first-in-human use of the AGENT paclitaxel-coated balloon in the United States, guided by patient-specific 3-dimensional coronary reconstruction and computational simulations. This computational simulation-informed strategy identified stiff fibrotic ISR, guiding lesion preparation with excimer laser coronary atherectomy, and noncompliant and cutting balloon inflations before drug-coated balloon deployment. Recurrent ISR at 8 months was successfully treated using the same simulation-guided approach with optimized device sizing.
Discussion:
Patient-specific computational simulations that integrated individual anatomy, physiology, and biology provided guidance on lesion preparation and device selection, leading to favorable clinical outcomes.
Novelty:
This report presents the first computational simulation-guided drug-coated balloon treatment of ISR integrating patient-specific anatomy, physiology, and biology.
Take-Home Messages:
Computational simulations combined with intracoronary imaging can enhance preprocedural planning, device selection, and outcomes in coronary interventions.
