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Updated: Mar 21, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
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Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

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Thrombolytic therapy before percutaneous coronary intervention improves short-term cardiac function evaluated by

Jiani Yin1,2, Hao Gong1, Yunfei Wang1

  • 1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.

Acta Radiologica (Stockholm, Sweden : 1987)
|March 19, 2026
PubMed

Insights

Half-dose recombinant staphylokinase (r-SAK) before percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients improved cardiac function and strain without increasing adverse events.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomedical Imaging

Background:

  • Thrombolytic therapy before percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is debated.
  • Further research is needed to assess the benefits of pre-PCI thrombolysis.

Purpose of the Study:

  • To evaluate the efficacy of a half-dose recombinant staphylokinase (r-SAK) intravenous bolus administered before PCI in STEMI patients.

Main Methods:

  • STEMI patients were randomized to receive either r-SAK or normal saline before PCI.
  • Cardiac magnetic resonance (CMR) assessed cardiac function, myocardial characteristics, and strain at 5 days post-MI.
  • Segments were categorized by late gadolinium enhancement (LGE) extent.

Main Results:

  • The r-SAK group (n=33) showed improved left ventricular ejection fraction and cardiac output index compared to the normal saline group (n=31).
  • No significant differences were observed in infarct size, area at risk, microvascular obstruction (MVO), or intramyocardial hemorrhage (IMH).
  • Patients receiving r-SAK demonstrated significantly better segmental longitudinal strain and improved segmental circumferential strain in LGE segments.

Conclusions:

  • A single half-dose r-SAK bolus before PCI in STEMI patients improved short-term cardiac function and strain.
  • This approach did not increase the incidence of MVO or IMH, suggesting a favorable safety profile.

Keywords:
Cardiac magnetic resonanceST-segment elevation myocardial infarctionthrombolytic therapy

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