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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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From center to edge: Prognostic implications of spatial metabolic heterogeneity, normalized hotspot-to-centroid and perimeter distance, on PET imaging. A systematic review and meta-analysis.

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Dosimetry and pharmacokinetics of [<sup>223</sup>Ra]Ra-dichloride alpha therapy in prostate cancer patients with bone metastases.

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AI-augmented thyroid scintigraphy for robust classification of disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
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Diagnostic utility of FAPI PET/CT in radioiodine-refractory thyroid cancer and TENIS syndrome: a systematic review.

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Simultaneous partial volume correction and denoising of brain PET images, using transformers and transfer learning.

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FAP-Targeted Theranostics in Advanced Sarcoma: A Pilot Study of ⁶⁸Ga-FAPI-46 Imaging and ¹⁷⁷Lu-FAPI-2286 Therapy.

Clinical nuclear medicine·2026

Related Experiment Video

Updated: Jun 30, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Imaging tumor microenvironment: clinical experience with 68Ga-FAPI PET/CT across multiple cancer types.

Ahmed K Al-Timeemi1, Alzahraa I Al-Timeemi2, Jasim Al-Ibraheemi3

  • 1Department of Nuclear Medicine, Al-Loaloa PET Center, Al-Kafeel Hospital, College of Medicine, University of Kerbala, Kerbala, Iraq.

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|March 19, 2026
PubMed
Summary

68Ga-FAPI-46 PET/CT imaging shows high contrast across many cancer types, especially those with significant stromal components. This technique offers a promising alternative to 18F-FDG PET/CT for improved tumor visualization and assessment.

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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
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Area of Science:

  • Nuclear Medicine
  • Oncology Imaging
  • Radiopharmaceuticals

Background:

  • Fibroblast activation protein (FAP) is a stromal marker highly expressed in various cancers.
  • FAP-targeted positron emission tomography (PET) imaging offers a potential diagnostic avenue.
  • 68Ga-labeled fibroblast activation protein inhibitor (FAPI)-46 is a novel PET tracer.

Purpose of the Study:

  • To evaluate the clinical performance of 68Ga-FAPI-46 PET/CT in a diverse cancer patient cohort.
  • To assess the diagnostic utility of 68Ga-FAPI-46 PET/CT in cases with inconclusive conventional imaging or 18F-FDG PET/CT results.

Main Methods:

  • Retrospective analysis of 22 patients with histopathologically confirmed cancers.
  • All patients underwent 68Ga-FAPI-46 PET/CT.
  • Tumor uptake was quantified using SUVmax and tumor-to-background ratio (TBR); malignancy was confirmed by histopathology or follow-up.

Main Results:

  • 115 lesions across 12 cancer types were evaluated.
  • Highest 68Ga-FAPI-46 avidity was observed in sarcoma, breast cancer, and cholangiocarcinoma.
  • High TBRs were achieved due to low background activity, indicating excellent image contrast.

Conclusions:

  • 68Ga-FAPI-46 PET/CT provides high-contrast imaging across a broad range of malignancies.
  • The modality shows particular promise for visualizing tumors with significant stromal components.
  • This technique may enhance tumor staging, restaging, and therapy assessment, especially when 18F-FDG PET/CT is suboptimal.