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Published on: December 15, 2010
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Recent advances of nanoparticles for ischemic stroke therapy
Tian Yun1,2, Yujie Hu2, Yihui Deng3
1Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Nanomedicine (London, England)
|March 19, 2026
Summary
Nanoparticles offer a promising new approach for treating ischemic stroke (IS) by overcoming the blood-brain barrier to deliver drugs effectively. This review highlights their potential for recanalization and neuroprotection in IS therapy.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Pharmacology
Background:
- Ischemic stroke (IS) is a major cause of global disability and mortality.
- Current treatments for IS face limitations due to the blood-brain barrier (BBB).
Purpose of the Study:
- To review the current advancements in nanoparticle (NP)-based therapies for ischemic stroke.
- To explore the potential of NPs in overcoming BBB limitations for IS treatment.
Main Methods:
- Comprehensive literature search of PubMed, Web of Science, and Google Scholar (Jan 2010 - Sep 2025).
- Focused on NP-based drug delivery systems for IS recanalization and neuroprotection.
Main Results:
- NPs demonstrate enhanced drug targeting to IS regions, improving therapeutic efficacy.
- NPs show potential for both recanalization and neuroprotective strategies in IS.
Conclusions:
- Nanoparticle-based systems represent a significant advancement in IS therapy.
- Further research is needed to address translational challenges for clinical application of NP-based IS treatments.
