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Updated: Mar 21, 2026
Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Base-Catalyzed Hydrothiolation of Dehydroalanine Peptides
Xiaotong Song1, Mu Chen1, Xinwei Hu1
1Department of Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, P.R. China.
None:
Herein, we develop a metal-free catalytic method for synthesizing sulfur-containing peptide derivatives through the reaction of dehydroalanine peptides with thiols under mild and simple conditions. This hydrothiolation enables selective construction of various C-S bonds containing sensitive groups with certain compounds being obtained in nearly stoichiometric yields. The methodology demonstrates broad functional group tolerance and high selectivity, allowing for the preparation of monofunctionalized organosulfur compounds.
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