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Human GlyRα2 pore dynamics in gating and inhibition

Emily Klemm1, Eric Gibbs2, Madeleine Stauffer3

  • 1Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106-4970, USA; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA; Medical Scientist Training Program, Case Western Reserve University, Cleveland, OH 44106-4970, USA.

Structure (London, England : 1993)
|March 19, 2026
PubMed
Summary

Structural insights into glycine receptors (GlyRs) reveal the intrinsic asymmetry of the GlyRα2 subtype. This finding provides a foundation for understanding GlyRα2

Keywords:
allosteryasymmetrychannel gatingcryo-EMion channels

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