Related Experiment Video
Updated: Mar 21, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Global differences in thyroid autoimmunity and hypothyroidism among children with type 1 diabetes: data from the
Dalia Al-Abdulrazzaq1, Stefanie Lazinger2, Maja Raicevic3
1Department of Pediatrics, College of Medicine, Kuwait University, Kuwait; Department of Population Health, Dasman Diabetes Institute, Kuwait.
Aims:
This study aims to report on the global differences in the prevalence of thyroid autoimmunity and hypothyroidism among children with T1D registered in the SWEET database and identifying the associated characteristics.
Methods:
Children aged ≤18 years registered with T1D in the SWEET database between 2012-2022, and with information on thyroid autoimmunity/disease screening, have been included in the study.
Results:
Among the total of children registered, 19,225 children had fulfilled the inclusion criteria. The prevalence of positive thyroid autoimmunity and hypothyroidism in the study cohort was 13.2% and 9.9% respectively. The adjusted prevalence of thyroid autoimmunity and hypothyroidism were highest in South America at 16.3%, 95% CI 13.1-20.1 and 17.1%, 95% CI 13.9-21.0 respectively. Age, gender and geographical region were identified as a predictive factor for the development of thyroid autoimmunity and hypothyroidism within the study cohort. Diabetes duration and BMI-Z scores were additional predictive factors for the development of hypothyroidism.
Conclusion:
Future research should clarify the genetic and environmental factors underlying regional disparities in thyroid autoimmunity and disease among children with T1D. Region-specific, evidence-based screening strategies tailored to local prevalence and risk profiles are needed to optimize early detection and clinical outcomes.
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Symptoms, Diagnosis, and Complications
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

