Ménétrier's disease with coexistent signet ring cell carcinoma: a rare presentation with peritoneal metastasis
Mangesh Londhe1, Neil Shah2, Charusheela Gore3
1Department of Pathology, Dr D Y Patil Vidyapeeth (Deemed to be University), Pune, Pune, India.
Abstract:
Ménétrier's disease (MD) is an uncommon hypertrophic protein-losing gastropathy marked by hypertrophied gastric rugae and hypoalbuminaemia. While MD increases the risk of gastric adenocarcinoma, its correlation with signet ring cell carcinoma (SRCC) is exceptionally uncommon. We present a woman in her 50s, who had abdominal pain and emesis. Oesophagogastroduodenoscopy demonstrated significantly hypertrophied rugal folds accompanied by oedematous mucosa, whereas histopathological analysis indicated foveolar hyperplasia compatible with mucosal disease. A minor concentration of signet ring cells was also seen, corroborated by periodic acid Schiff (PAS) staining. Positron emission tomography (PET) imaging exhibited low-grade fluorodeoxyglucose uptake and omental stranding, whereas ascitic fluid and omental biopsy confirmed metastatic SRCC deposits. The case was addressed with palliative chemotherapy. This appears to be the inaugural documented instance of MD linked to SRCC from the Indian subcontinent. This research emphasises the significance of thorough histological analysis in MD, since the distinctive foveolar hyperplasia may conceal modest malignant foci.
Related Concept Videos
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Abnormal Proliferation


