Related Experiment Video
Updated: Mar 21, 2026
10:05
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
Published on: March 20, 2017
12.8K
Whole-Body Transformation in Obese Patients Undergoing Metabolic Surgery: Insights From Automated Multiorgan
Silke Potthast1, Martin Segeroth2, Jakob Wasserthal2
1Department of Radiology, Limmattal Hospital, Schlieren, Switzerland (S.P.).
Academic Radiology
|March 19, 2026
Summary
Automated segmentation accurately tracks subtle changes in body composition after metabolic surgery. This method reveals significant shifts in fat, organ, and muscle volumes and characteristics, aiding in understanding post-surgery transformations.
Area of Science:
- Radiology and Medical Imaging
- Surgical Oncology
- Obesity Medicine
Background:
- Metabolic surgery is a key intervention for severe obesity.
- Assessing body composition changes post-surgery is crucial for patient management.
- Subtle volumetric and tissue characteristic alterations may impact outcomes.
Purpose of the Study:
- To evaluate the efficacy of automated segmentation for detecting subtle changes in volume and tissue characteristics.
- To analyze these changes in obese patients undergoing metabolic surgery.
Main Methods:
- 1877 preoperative/postoperative CT scans analyzed using automated multiorgan segmentation.
- Nine compartments assessed: subcutaneous/peritoneal fat, skeletal muscle, liver, spleen, kidneys, pancreas, L1 vertebral body.
- Statistical analysis included Wilcoxon signed-rank test and generalized linear mixed models.
Main Results:
- Significant reductions in subcutaneous (25%) and visceral fat (29%) volumes observed.
- Increased Hounsfield Unit (HU) values in fat post-surgery indicate tissue quality changes.
- Organ volumes (liver, spleen, kidneys, pancreas) decreased by 7-11%.
- Skeletal muscle volume decreased by 4% with a 4% increase in HU.
- Male gender was associated with larger volumes and greater postoperative changes.
Conclusions:
- Automated, operator-independent segmentation effectively quantifies subtle volumetric and tissue characteristic changes post-metabolic surgery.
- These findings highlight the complex body composition remodeling following surgery-induced weight loss.
Related Concept Videos
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
360
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
360
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
272
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
272
01:18Metabolic States of the Body: The Postabsorptive State
1.6K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.6K
01:21Drug Dosing: Obese Patients
333
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
333
01:24Obesity
1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
01:24Metabolic States of the Body: Fasting and Starvation
3.3K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.3K