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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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CPAP to Reduce the Risk of Cancer in OSA?-A Meta-Analysis of 3 RCTs.

Jenny Theorell-Haglöw1, Yüksel Peker2,3,4,5, Nathaniel S Marshall6

  • 1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.

Journal of Sleep Research
|March 20, 2026
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) may not increase cancer risk. Continuous positive airway pressure (CPAP) treatment for OSA showed no significant difference in cancer incidence across three trials.

Keywords:
CPAPcancerobstructive sleep apnea

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Area of Science:

  • Sleep Medicine
  • Oncology
  • Respiratory Medicine

Background:

  • Obstructive sleep apnea (OSA) is linked to intermittent hypoxia, a potential cancer promoter.
  • Understanding the impact of continuous positive airway pressure (CPAP) on cancer incidence in OSA patients is crucial.

Purpose of the Study:

  • To meta-analyze randomized controlled trials evaluating cancer incidence in OSA patients treated with CPAP versus control.
  • To assess if CPAP therapy affects the risk of developing neoplasms in individuals with OSA.

Main Methods:

  • Meta-analysis of three randomized controlled trials (SAVE, RICCADSA, ISAACC).
  • Inclusion of adverse event data on neoplasms.
  • Comparison of cancer incidence between CPAP and control groups.

Main Results:

  • Cancer incidence was similar across the included trials.
  • Meta-analysis revealed no statistically significant difference in cancer incidence between CPAP and control groups (CI 0.55-1.68).

Conclusions:

  • Continuous positive airway pressure treatment for obstructive sleep apnea does not appear to significantly reduce the risk of incident cancers.
  • Current evidence suggests no marked impact of CPAP on cancer development in OSA patients.