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Updated: Mar 21, 2026
Engineering a Bilayered Hydrogel to Control ASC Differentiation
Published on: May 25, 2012
Bio-heterojunction-engineered recombinant collagen hydrogel orchestrates multimodal sterilization and
Chongyi Li1,2,3,4, Zewen Chang1,2,3,4, Yuxi Zhang1,2,3,4
1Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710127, China.
None:
Multidrug-resistant (MDR) bacterial infections, notably methicillin-resistant Staphylococcus aureus (MRSA), necessitate innovative antibiotic-free wound therapies. Here, a bio-heterojunction-integrated recombinant collagen hydrogel (CAP@MXene/CuTCPP) is designed that synergistically combines photothermal therapy (PTT), photodynamic therapy (PDT), and peroxidase-like (POD-like) activity for multimodal antibacterial action. The borate-bonded dynamically crosslinked hydrogel is composed of polyvinyl alcohol (PVA), 3-aminophenylboronic acid (APBA)-modified recombinant collagen (CF-1552), and MXene/CuTCPP bio-heterojunctions (bio-HJs). Under 808 nm near-infrared (NIR) irradiation, the MXene/CuTCPP bio-HJs exhibit a high photothermal conversion efficiency (44.51%), inducing localized hyperthermia to disrupt bacterial membranes. Importantly, the construction of a Schottky junction at the MXene/CuTCPP interface significantly accelerates photo-excited electron transfer, thereby catalytically amplifying the production of additional ROS (1O2, ·O2 -, ·OH) for synergistic bacterial eradication. This triple antibacterial mechanism ensures a 99.95% MRSA eradication rate without inducing drug resistance, while effectively removing the biofilm. In vivo, the hydrogel accelerates wound closure (98% by day 11) not only by providing a biomimetic scaffold but also by regulating the polarization of macrophages from M1 to M2, and significantly promoting angiogenesis. This work presents a biocompatible and self-adaptable platform that overcomes the killing-healing trade-off through synergistic energy/charge transfer integration, offering insights for advanced immunomodulatory wound management.
