Related Experiment Video
Updated: Mar 21, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Intestinal Stenosis Related to Immune Checkpoint Inhibitors Caused by Sintilimab: A Case Report
Hong Yan Li1, Yue Liu1, Si Leng Hu1
1Gastroenterology Department, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
None:
Immune checkpoint inhibitors (ICIs) as an immunotherapy have significantly prolonged the overall survival (OS) and progression-free survival (PFS) of patients with various advanced cancers, and have significantly increased the objective response rate. However, excessive activation of the immune system may attack normal organs, triggering a series of immune-related adverse reactions. Among them, due to the relatively high incidence of immune-mediated colitis (IMC), it is particularly worthy of attention. Xindili Antibody is a fully human immunoglobulin G4 monoclonal antibody that targets the programmed cell death receptor 1 (PD-1) pathway. It is of great significance in cancer immunotherapy and has shown good anti-tumor effects in various malignant tumors. Here, we report a case of a 64-year-old male with colorectal cancer and lung metastasis. After using Sintilimab, the patient developed inflammatory intestinal obstruction. The colonic stenosis caused by immune checkpoint inhibitors may be the result of the combined effects of chronic immune inflammation, microbial flora imbalance, and disrupted tissue repair. This case report emphasizes the importance of early identification and appropriate intervention to prevent the permanent interruption of immune checkpoint inhibitor treatment and the prevention of colitis complications.
Related Concept Videos
Mitral Stenosis I: Introduction
Drugs for Treatment of Constipation-Predominant IBS
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...

